A high-speed train running between Strasbourg in eastern France and Paris derailed after a landslide, injuring 22 people including one seriously.

The driver, who was seriously injured, managed to slam on the emergency brakes and bring the train to a halt.

The initial assessment is that there is one injured person who is an extremely urgent case and has been evacuated by a Dragon 67 helicopter to Strasbourg-Hautepierre hospital, and 21 people who are being treated as relatively urgent cases.

State rail company said the train driver was evacuated by helicopter, and a major landslide had caused the accident. The train, carrying 300 passengers, was travelling from Colmar in eastern France to the capital and was racing along at 270 kilometres per hour when it jumped the tracks.